Horsehead Crossing, is a ford of the Pecos River, located near Farm Road 11 and twelve miles northwest of Girvin in northeastern Pecos County. The area was one of the few crossing points on the Pecos River before the twentieth century. The area was covered with horse, cattle, and mule skeletons due to quicksand and poisoning by briny water. Horse skulls were once placed on top of mesquite trees to mark the crossing, hence it name - Horsehead Crossing.

Commanche and Kiowa raiding parties found the first water hole in more than sixty miles there when coming back from Mexico. In 1849 an expedition headed by John S. (Rip) Ford found the crossing in search of a route to El Paso.

Within a few years, stagecoach routes were established by the Butterfield Overnight Mail.

In the 1860s cattlemen frequently drove their herds across Horsehead Crossing. After losing hundreds of cattle in the desert and the river, Charles Goodnight described the Pecos as the "graveyard of the cowman's hopes."

The crossing was used by Confederate troops during the War of Northern Aggression.